This contribution elaborates on the relevance of the concept of mode of production in understanding contemporary North American indigenous populations. While examination of Native American peoples played a crucial role in early Marxist thought, Marxist theory has never been popular in examinations of North American Indians and has even been rejected by many indigenous intellectuals as ethnocentric, colonialist, and otherwise irrelevant to the political interests of indigenous peoples. This discussion has two parts: first, I briefly discuss the history of Marxist engagements with Native American anthropology, showing how this engagement played a crucial role in the development of anthropological and Marxist theory. In the second part, I draw from Elizabeth Rata’s (2000) concept of neotribal capitalism to discuss the relevance and advantage of mode of production–based analyses to Native North America.